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Table 2 Priority setting criteria. Main sources

From: Systematic review for the development of a pharmaceutical and medical products prioritization framework

Domain

Considered criteria

Alternative categorizations / subgroupings

Need for intervention

-Severity of the disease / condition

Target disease

- Population size

- Severity of the disease

-Unmet need / availability of alternatives

-Determinants of the disease

-Burden of illness / threat to life

-Economic burden of the disease

-Epidemiology

Therapeutic context

-Therapeutic alternatives / need not met

-Need

-Clinical practice guidelines and protocols

-Existing use

Health results

-Benefits in health / clinical

Clinical benefits

-Efficacy / Effectiveness

- General clinical benefits

- Safety / tolerability

-Effect on mortality

-Health perceived by the patient

-Effect on longevity

-Quality of care

-Effect on quality of life

Health perceived by the patient:

-Quality of life

- Autonomy

- Impact on dignity

- Improved use / administration

Adequacy

- Efficiency and safety

- Effectiveness

Response level

- Quality of care received by the patient

- Burden of disease

Type of benefit of the intervention

-Preventive benefits

 

-Therapeutic benefits

Economic consequences / economic impact

-Costs of the intervention

Efficiency

- Medical / health costs

- Cost effectiveness / benefit

- Non-medical costs (productivity, cost, patients, caregivers)

- Budget impact

-Impoverishment for the patient

- Costs

- Budget impact

Financing

-Financial impact

- Unit cost

-Impact on productivity

- Budget impact

-Impact on other services

- Financing agent

-Efficiency and opportunity cost

Cost of opportunity and affordability (context-dependent criteria)

-Cost-effectiveness

- Opportunity cost and if the system can afford it

Existing knowledge about the intervention / Quality and uncertainty of the evidence

-Evidence available

Other considerations

-Quality of the evidence

Quality of clinical and economic evidence

-Relevance of the evidence

Consistency with strategic aspects

-Uncertainty of the evidence

-Expert consensus / clinical practice guidelines

Implementation and complexity of the intervention / Feasibility

-Regulatory requirements / legislation

-Organizational requirements

-Technological requirements

-Requirements of personnel

-Training / personal skills requirements

-Information requirements

-Implementation flexibility

-Features of the intervention

-Appropriate use

-Barriers and acceptability

-Integration and efficiency of the system

-Sustainability

-Accessibility to the population

Ethics and justice

-Population priorities

Priority, ethics and justice

-Access

- Low socioeconomic status

-Vulnerability

- Children (0–5 years old or elderly)

-Utility

- Subjects of productive age

-Solidarity

- Women in productive age

-Ethics and moral aspects

- Remote communities

- Therapeutic specific areas

- Response behavior

- Rare diseases

- Specific groups of patients

Equity

- General

- Accessibility

- Accessibility for the individual

Other ethical and social values

- Autonomy

- Value public health

- Impact in future generations

- Risk social and financial

- Catastrophic sanitary cost

- Economic productivity and care for third parties

- Rare diseases-Population priorities

Global context

-Mandate and mission of the health system

Governance / leadership

-Alignment with regulations and strategies

- Congruence with prior prioritization

- Global priorities / alignment with priority lines (vulnerable groups, disabled, diseases, rare, etc.)

- Cultural acceptability

-Financial Restriction

- Political acceptability

-Incentives

- Acceptability of interest groups

-Political aspects

- Legal Barriers

- Historical aspects

-Cultural aspects

-Degree of innovation

-Collaboration and leadership

-Implementation of patients

-Pressure of different interest groups

-Environmental impact

  1. Main references used: EVIDEM tool [10, 11] and Guindo [13], Golan [14], Tanios [15], Tromp [16] studies