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Table 3 Clinical characteristic of COVID-19 patients, (n = 4043)

From: The landscape of antibiotic usage among COVID-19 patients in the early phase of pandemic: a Malaysian national perspective

Variables

 

n (%)

Antibiotic use^

p-value*

Symptoms of presentation

Cough

1620 (40.1)

457 (28.2)

 < 0.001

Fever

1565 (38.7)

433 (27.7)

 < 0.001

Sore throat

713 (17.6)

149 (20.9)

0.005

Rhinorrhoea

550 (13.6)

104 (18.9)

0.272

Dyspnoea

284 (7.0)

142 (50.0)

 < 0.001

Diarrhoea

279 (6.9)

100 (35.8)

 < 0.001

Myalgia

217 (5.4)

52 (24.0)

0.007

Malaise

183 (4.5)

72 (38.7)

 < 0.001

Anosmia

155 (3.8)

10 (6.5)

 < 0.001

Headache

154 (3.8)

26 (16.9)

0.898

Arthralgia

114 (2.8)

29 (25.4)

0.019

Nausea/vomiting

100 (2.5)

38 (38.0)

 < 0.001

Ageusia

38 (0.9)

3 (7.9)

0.125#

Abdominal pain

36 (0.9)

13 (36.1)

0.003

Chest pain

50 (1.2)

21 (42.0)

 < 0.001

Skin rash

9 (0.2)

2 (22.2)

0.659#

Conjunctivitis

9 (0.2)

0 (0.0)

0.374#

Wheezing

6 (0.1)

3 (50.0)

0.104#

Ear pain

5 (0.1)

0 (0.0)

0.168#

Haemorrhage

3 (0.1)

3 (100.0)

 < 0.005#

Clinical severity stage on admission#

Stage 1

1634 (40.4)

64 (3.9)

 < 0.001

Stage 2

1487 (36.8)

244 (16.4)

Stage 3

644 (15.9)

186 (28.9)

Stage 4

221 (5.5)

145 (69.0)

Stage 5

57 (1.4)

51 (17.1)

Worst clinical stage#

Stage 1

1345 (33.3)

16 (1.2)

 < 0.001

Stage 2

1347 (33.3)

154 (11.4)

Stage 3

896 (22.2)

200 (22.3)

Stage 4

287 (7.1)

166 (60.1)

Stage 5

168 (4.2)

157 (93.5)

Out of normal range FBC (on admission)

White blood cells (n = 3661)

302 (8.3)

111 (15.9)

 < 0.001

Haemoglobin (n = 3661)

146 (4.0)

65 (9.3)

 < 0.001

Hematocrit (n = 3638)

2486 (68.3)

271 (39.3)

 < 0.001

Platelets (n = 3661)

417 (11.4)

102 (14.6)

 < 0.001

Neutrophil count (n = 3548)

413 (11.6)

152 (21.8)

 < 0.001

Lymphocyte count (n = 3573)

141 (4.0)

55 (7.9)

 < 0.001

Out of normal range renal function test (on admission)

Serum creatinine (n = 3493)

2025 (58.0)

367 (52.6)

0.005

Blood urea nitrogen (n = 3505)

678 (19.3)

228 (32.7)

 < 0.001

Sodium (n = 3507)

469 (13.4)

230 (33.0)

 < 0.001

Potassium (n = 3500)

855 (24.4)

186 (26.6)

 < 0.001

Out of normal range CRP (n = 2522)

346 (13.7)

188 (26.9)

 < 0.001

Use of anti-fungal agents

50 (1.2)

40 (80.0)

 < 0.001

Use of anti-malarial agents

1935 (47.9)

570 (29.5)

 < 0.001

Use of anti-viral agents

1020 (33.6)

549 (53.8)

 < 0.001

Oxygen therapy

459 (11.4)

329 (71.7)

 < 0.001

Corticosteroid therapy

124 (3.1)

108 (87.1)

 < 0.001

Admission to ICU/HDU

192 (4.8)

176 (91.7)

 < 0.001

Duration of hospitalization, median (IQR)

11.00 (9.00)

 

 < 0.001§

Patient outcome

Alive

3966 (98.1)

631 (15.9)

 < 0.001

Death

77 (1.9)

67 (87.0)

  1. #1: asymptomatic, 2: symptomatic, no pneumonia, 3: symptomatic, pneumonia, 4: symptomatic, pneumonia, requiring supplemental oxygen, 5: critically ill with multi-organ involvement
  2. IQR interquartile range; FBC full blood counts; CRP C-reactive protein; ICU Intensive Care Unit; HDU High Dependency Unit
  3. ^ Antibiotic use during hospitalization
  4. # Fisher's Exact test
  5. * Chi-Square test
  6. § Mann–Whitney U test